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AMT hydrochloride

Cat. No. 0871 5 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent, selective iNOS inhibitor
Chemical Name: 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
Datasheet
Citations (5)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AMT hydrochloride

AMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

Technical Data for AMT hydrochloride

M. Wt 166.67
Formula C5H10N2S.HCl
Storage Desiccate at +4°C
CAS Number 21463-31-0
PubChem ID 2733501
InChI Key HVJCRMIQAMEJNM-UHFFFAOYSA-N
Smiles NC1=NCCC(S1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AMT hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10

Preparing Stock Solutions for AMT hydrochloride

The following data is based on the product molecular weight 166.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 60 mL 299.99 mL 599.99 mL
0.5 mM 12 mL 60 mL 120 mL
1 mM 6 mL 30 mL 60 mL
5 mM 1.2 mL 6 mL 12 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for AMT hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for AMT hydrochloride

References are publications that support the biological activity of the product.

Liao et al (2006) Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 20 E1196 PMID: 16877524

Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889

Yu et al (2005) Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 566 327 PMID: 15845578

If you know of a relevant reference for AMT hydrochloride, please let us know.

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5 Citations for AMT hydrochloride

Citations are publications that use Tocris products. Selected citations for AMT hydrochloride include:

Lee et al (2018) Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways. J Ginseng Res 42 476 PMID: 30337808

Lee et al (2016) Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents. PLoS One 24 67 PMID: 26759704

Wong et al (2017) Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta. Br J Pharmacol 174 718 PMID: 28138957

Messlinger et al (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol 129 1397 PMID: 10742295

Do you know of a great paper that uses AMT hydrochloride from Tocris? Please let us know.

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