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Submit ReviewAMTB hydrochloride
Description: TRPM8 blocker
Chemical Name: N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for AMTB hydrochloride
AMTB hydrochloride is a TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23).
Technical Data for AMTB hydrochloride
| M. Wt | 430.99 |
| Formula | C23H26N2O2S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 926023-82-7 |
| PubChem ID | 16095383 |
| InChI Key | UDXGBANGPYONOK-UHFFFAOYSA-N |
| Smiles | O=C(N(CC2=CC=CS2)CCCN)C1=C(OCC3=CC(C)=CC=C3)C=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AMTB hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.1 | 100 | |
| DMSO | 43.1 | 100 |
Preparing Stock Solutions for AMTB hydrochloride
The following data is based on the product molecular weight 430.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.6 mL | 23.2 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for AMTB hydrochloride
References for AMTB hydrochloride
References are publications that support the biological activity of the product.
Lashinger et al (2008) AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am.J.Physiol.Renal Physiol. 295 F803 PMID: 18562636
If you know of a relevant reference for AMTB hydrochloride, please let us know.
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Keywords: AMTB hydrochloride, AMTB hydrochloride supplier, TRPM8, transient, receptor, potential, channels, blockers, TRPM, 3989, Tocris Bioscience
7 Citations for AMTB hydrochloride
Citations are publications that use Tocris products. Selected citations for AMTB hydrochloride include:
Liu et al (2015) Menthol suppresses laryngeal C-fiber hypersensitivity to cigarette smoke in a rat model of gastroesophageal reflux disease: the role of TRPM8. J Appl Physiol (1985) 118 635 PMID: 25539933
Sałat and Filipek (2015) Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. Biochem J 16 167 PMID: 25743118
Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35 PMID: 26330615
Mueller-Tribbensee et al (2015) Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS One 10 e0128242 PMID: 26207981
Laura N et al (2019) Growth at Cold Temperature Increases the Number of Motor Neurons to Optimize Locomotor Function. Curr Biol 29 1787-1799.e5 PMID: 31130453
Diver et al (2019) Structural insights into TRPM8 inhibition and desensitization. Science 365 1434 PMID: 31488702
Melikov et al (2015) Efficient entry of cell-penetrating peptide nona-arginine into adherent cells involves a transient increase in intracellular calcium. Autophagy 471 221 PMID: 26272944
Do you know of a great paper that uses AMTB hydrochloride from Tocris? Please let us know.
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