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Angiotensin A

Cat. No. 5335 Submit a Review Datasheet / COA / SDS

Discontinued Product

5335 has been discontinued.

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Description: Potent endogenous vasoconstrictor peptide - derivative of angiotensin II (Cat. No. 1158)
Datasheet
Citations
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Biological Activity Technical Data Datasheets References

Biological Activity for Angiotensin A

Angiotensin A is a potent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).

Technical Data for Angiotensin A

M. Wt 1002.18
Formula C49H71N13O10
Sequence ARVYIHPF
Storage Store at -20°C
CAS Number 51833-76-2
PubChem ID 91691124
InChI Key CHCOFDZSJYMQMX-NOQNJSOHSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Angiotensin A

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Angiotensin A

References are publications that support the biological activity of the product.

Yang et al (2011) Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent. Hypertension 57 956 PMID: 21464395

Coutinho et al (2013) Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system. J.Renin Angiotensin Aldosterone Syst. 15 480 PMID: 23386282

Villela et al (2014) Alamandine: a new member of the angiotensin family. Curr.Opin.Nephrol.Hypertens. 23 130 PMID: 24389733

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Keywords: Angiotensin A, Angiotensin A supplier, Angiotensin, A, II, receptors, potent, endogenous, vasoconstrictor, peptide, AT1, AT2, agonists, Non-selective, AT, Receptors, 5335, Tocris Bioscience

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