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Submit ReviewAngiotensin I (human, mouse, rat)
Description: Endogenous precursor to angiotensin II (Cat. No. 1158)
Purity: ≥95% (HPLC)
Biological Activity for Angiotensin I (human, mouse, rat)
Angiotensin I (human, mouse, rat) is an endogenous peptide substrate for angiotensin converting enzyme (ACE) and ACE2; precursor to the vasoconstrictor peptide angiotensin II (Cat. No. 1158).
Technical Data for Angiotensin I (human, mouse, rat)
| M. Wt | 1296.5 |
| Formula | C62H89N17O14 |
| Sequence | DRVYIHPFHL |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 484-42-4 |
| PubChem ID | 3081372 |
| InChI Key | ORWYRWWVDCYOMK-HBZPZAIKSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Angiotensin I (human, mouse, rat)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Angiotensin I (human, mouse, rat)
References for Angiotensin I (human, mouse, rat)
References are publications that support the biological activity of the product.
Erdo (1976) Conversion of angiotensin I to angiotensin II. Am.J.Med. 60 749 PMID: 190881
Erdos and Skidgel (1990) Renal metabolism of angiotensin I and II. Kidney Int.Suppl. 30 S24 PMID: 2175370
Manabe et al (1989) Endothelium-dependent contractions induced by angiotensin I and angiotensin II in canine cerebral artery. J.Pharmacol.Exp.Ther. 251 317 PMID: 2795464
If you know of a relevant reference for Angiotensin I (human, mouse, rat), please let us know.
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