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Submit ReviewApocynin
Description: NADPH-oxidase inhibitor
Chemical Name: 4'-Hydroxy-3'-methoxyacetophenone
Purity: ≥99% (HPLC)
Biological Activity for Apocynin
Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.
Compound Libraries for Apocynin
Apocynin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Apocynin
| M. Wt | 166.17 |
| Formula | C9H10O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 498-02-2 |
| PubChem ID | 2214 |
| InChI Key | DFYRUELUNQRZTB-UHFFFAOYSA-N |
| Smiles | CC(C1=CC(OC)=C(O)C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Apocynin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 100 | |
| ethanol | 16.62 | 100 |
Preparing Stock Solutions for Apocynin
The following data is based on the product molecular weight 166.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 5 mM | 1.2 mL | 6.02 mL | 12.04 mL |
| 10 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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Product Datasheets for Apocynin
References for Apocynin
References are publications that support the biological activity of the product.
Stolk et al (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 11 95 PMID: 8018341
Impellizzeri et al (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 81 636 PMID: 21147071
Heumüller et al (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51 211 PMID: 18086956
If you know of a relevant reference for Apocynin, please let us know.
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Keywords: Apocynin, Apocynin supplier, Apocynin, NADPH, oxidases, inhibitors, inhibits, leukocytes, anti-inflammatory, peroxidases, Oxidase, 4663, Tocris Bioscience
11 Citations for Apocynin
Citations are publications that use Tocris products. Selected citations for Apocynin include:
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191
Timothy S et al (2021) Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol 207 1275-1287 PMID: 34389624
Kyung-Sun et al (2021) Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling. Cancers (Basel) 13 PMID: 33920802
Rita et al (2018) Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine. Glia 66 2353-2365 PMID: 30394585
Kyung-Sun et al (2022) Ginsenoside Rh1 Inhibits Angiotensin II-Induced Vascular Smooth Muscle Cell Migration and Proliferation through Suppression of the ROS-Mediated ERK1/2/p90RSK/KLF4 Signaling Pathway. Antioxidants (Basel) 11 PMID: 35453328
Chiao et al (2022) Interleukin-1 receptor antagonism leads to improved anaemia in a murine model of sickle cell disease and is associated with reduced ex vivo platelet-mediated erythrocyte sickling. Br J Haematol 196 1040-1051 PMID: 34786709
Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752
Rebecca L et al (2019) NADPH Oxidase Mediates Membrane Androgen Receptor-Induced Neurodegeneration. Endocrinology 160 947-963 PMID: 30811529
Richard S et al (2020) Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxide. J Nutr 150 55-63 PMID: 31504721
Michaeli et al (2017) Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment. Oncoimmunology 6 e1356965 PMID: 29147615
Hassler et al (2014) Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. Int J Mol Med 131 413 PMID: 25051888
Do you know of a great paper that uses Apocynin from Tocris? Please let us know.
Reviews for Apocynin
Average Rating: 5 (Based on 1 Review.)
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Apocynin.
By
Anonymous on 01/10/2018
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: brain slice
Apocynin is a NADPH oxidase inhibitor. It blocks NADPH oxidase in rat brain slice at 1mM.
Literature in this Area
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