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Submit ReviewAR-M 1000390 hydrochloride
Discontinued Product
4335 has been discontinued.
Description: Low-internalizing δ agonist
Chemical Name: N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)-benzamide hydrochloride
Purity: ≥97% (HPLC)
Biological Activity for AR-M 1000390 hydrochloride
AR-M 1000390 hydrochloride is a non-peptidic, low-internalizing δ-selective opioid receptor agonist; derivative of SNC 80 (Cat. No. 0764). Does not trigger acute desensitization of the analgesic response; reduces CFA-induced hyperalgesia. Brain penetrant following systemic administration.
Technical Data for AR-M 1000390 hydrochloride
| M. Wt | 384.94 |
| Formula | C23H28N2O.HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 209808-47-9 |
| PubChem ID | 76848958 |
| InChI Key | OTXTZCLQEGSAMW-UHFFFAOYSA-N |
| Smiles | O=C(N(CC)CC)C1=CC=C(/C(C3=CC=CC=C3)=C2\CCNCC2)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AR-M 1000390 hydrochloride
References for AR-M 1000390 hydrochloride
References are publications that support the biological activity of the product.
Marie et al (2003) Pharmacological characterization of AR-M1000390 at human opioid delta receptors. Life Sci. 73 1691 PMID: 12875901
Pradhan et al (2010) Ligand-directed trafficking of the δ-opioid receptor in vivo: Two paths toward analgesic tolerance. J.Neurosci. 30 16459 PMID: 21147985
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Keywords: AR-M 1000390 hydrochloride, AR-M 1000390 hydrochloride supplier, AR-M1000390, HCl, delta, opioids, δ-opioid, receptors, agonists, Delta, Opioid, Receptors, 4335, Tocris Bioscience
3 Citations for AR-M 1000390 hydrochloride
Citations are publications that use Tocris products. Selected citations for AR-M 1000390 hydrochloride include:
Stoeber et al (2018) A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action. Neuron 98 963 PMID: 29754753
Francesco Luigi et al (2023) Subcellular location defines GPCR signal transduction. Sci Adv 9 eadf6059 PMID: 37075112
Anika et al (2020) Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies. Sci Rep 10 8585 PMID: 32444688
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