Home / Product Type / PROTAC® Degraders & Targeted Protein Degradation / Protein Degraders / Negative Controls / ARCC 4 negative control

ARCC 4 negative control

Cat. No. 7255 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Negative control for ARCC 4 (Cat. No. 7254)
Chemical Name: (2S,4S)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ARCC 4 negative control

ARCC 4 negative control is a negative control for ARCC 4 (Cat. No. 7254). Binds androgen receptors (AR) without inducing degradation.

Technical Data for ARCC 4 negative control

M. Wt 1024.18
Formula C53H56F3N7O7S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2156588-26-8
PubChem ID 145746289
InChI Key DUPAJELXESPTNF-RNEKHSKBSA-N
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)NC(COCCCCOC4=CC=C(C5=CC=C(N6C(N(C7=CC(C(F)(F)F)=C(C#N)C=C7)C(C6(C)C)=O)=S)C=C5)C=C4)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ARCC 4 negative control

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 102.42 100

Preparing Stock Solutions for ARCC 4 negative control

The following data is based on the product molecular weight 1024.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.98 mL 4.88 mL 9.76 mL
5 mM 0.2 mL 0.98 mL 1.95 mL
10 mM 0.1 mL 0.49 mL 0.98 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for ARCC 4 negative control

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for ARCC 4 negative control

References are publications that support the biological activity of the product.

Salami et al (2018) Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun.Biol. 1 100 PMID: 30271980

If you know of a relevant reference for ARCC 4 negative control, please let us know.

View Related Products by Target

Keywords: ARCC 4 negative control, ARCC 4 negative control supplier, ARCC4, negative, control, PROTAC, PROTACs, degraders, degrades, androgen, receptors, AR, proteolysis-targeting, chimera, prostate, cancer, Negative, Controls, 7255, Tocris Bioscience

Citations for ARCC 4 negative control

Citations are publications that use Tocris products.

Currently there are no citations for ARCC 4 negative control. Do you know of a great paper that uses ARCC 4 negative control from Tocris? Please let us know.

Reviews for ARCC 4 negative control

There are currently no reviews for this product. Be the first to review ARCC 4 negative control and earn rewards!

Have you used ARCC 4 negative control?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia