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Submit Review[Arg14,Lys15]Nociceptin
Description: Highly potent and selective NOP agonist
Biological Activity for [Arg14,Lys15]Nociceptin
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.
Technical Data for [Arg14,Lys15]Nociceptin
| M. Wt | 1909.18 |
| Formula | C82H137N31O22 |
| Sequence | FGGFTGARKSARKRKNQ |
| Storage | Desiccate at -20°C |
| CAS Number | 236098-40-1 |
| PubChem ID | 16143911 |
| InChI Key | VULLMZOQBGUKAT-VUXBHJHDSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Arg14,Lys15]Nociceptin
References for [Arg14,Lys15]Nociceptin
References are publications that support the biological activity of the product.
Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223 PMID: 11906488
Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 278 493 PMID: 11097863
Rizzi et al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 300 57 PMID: 11752097
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Keywords: [Arg14,Lys15]-Nociceptin, [Arg14,Lys15]-Nociceptin supplier, potent, selective, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, 1590, Tocris Bioscience
1 Citation for [Arg14,Lys15]Nociceptin
Citations are publications that use Tocris products. Selected citations for [Arg14,Lys15]Nociceptin include:
Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736
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