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ARN 11391

Cat. No. 7909 Submit a Review Datasheet / COA / SDS
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Description: Potentiator of the IP3-gated calcium channel ITPR1
Chemical Name: 2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2H-pyran-2-yl)methoxy]phenyl]-2H-indazole-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ARN 11391

ARN 11391 is a potentiator of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1). It amplifies intracellular calcium ion signaling by acting directly on ITPR1. ARN 11391 also potentiates calcium signaling in cells expressing mutant ITPR1 which is associated with SCA29, a form of spinocerebellar ataxia.

Technical Data for ARN 11391

M. Wt 383.49
Formula C22H29N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1214569-31-9
PubChem ID 46969526
InChI Key WEHYVOUAIUTKKA-UHFFFAOYSA-N
Smiles O=C(C1=C2C(CCCC2)=NN1CC)NC3=C(OCC4OCCCC4)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ARN 11391

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.35 100
ethanol 38.35 100

Preparing Stock Solutions for ARN 11391

The following data is based on the product molecular weight 383.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for ARN 11391

References are publications that support the biological activity of the product.

Genovese et al (2022) Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening. PNAS Nexus 2 pgac288 PMID: 36712939

If you know of a relevant reference for ARN 11391, please let us know.

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Citations for ARN 11391

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