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Description: FAAH-like anandamide transporter (FLAT) inhibitor
Chemical Name: 4-[[4-(4-Hydroxyphenyl)-1-phthalazinyl]amino]-N-phenylbenzamide
Purity: ≥98% (HPLC)
Biological Activity for ARN 272
FAAH-like anandamide transporter (FLAT) inhibitor (IC50 = 1.8 μM); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB1-mediated nociceptive and inflammatory pain.
Technical Data for ARN 272
| M. Wt | 432.47 |
| Formula | C27H20N4O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 488793-85-7 |
| PubChem ID | 24802717 |
| InChI Key | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| Smiles | OC(C=C4)=CC=C4C2=NN=C(NC3=CC=C(C(NC5=CC=CC=C5)=O)C=C3)C1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ARN 272
References for ARN 272
References are publications that support the biological activity of the product.
Piscitelli and Marzo (2012) "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control. ACS Chem.Neurosci. 3 356 PMID: 22860203
Fu et al (2011) A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat.Neurosci. 15 64 PMID: 22101642
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Citations for ARN 272
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Currently there are no citations for ARN 272.
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