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Submit ReviewArtesunate
Description: Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
Chemical Name: 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
Purity: ≥98% (HPLC)
Biological Activity for Artesunate
Artesunate suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Aretesumate is an antimalarial (Plasmodium).
Technical Data for Artesunate
| M. Wt | 384.42 |
| Formula | C19H28O8 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 88495-63-0 |
| PubChem ID | 6917864 |
| InChI Key | FIHJKUPKCHIPAT-AHIGJZGOSA-N |
| Smiles | [H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@H]([C@@H]2C)OC(CCC(O)=O)=O)(O4)[H])C)[H])C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Artesunate
References for Artesunate
References are publications that support the biological activity of the product.
Meshnick et al (2002) Artemisinin: mechanisms of action, resistance and toxicity. In.J.Parasitol. 32 1655 PMID: 12435450
Jeong et al (2015) Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. Oncotarget. 6 33046 PMID: 26426994
Liu et al (2018) Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome. Inflammation 41 1546 PMID: 29730819
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Keywords: Artesunate, Artesunate supplier, malaria, antimalarial, ROS, inhibitors, inhibits, NLRP3, inflammasome, G2/M, phase, arrest, Plasmodium, falciparum, Inflammasomes, Cell, Cycle, Inhibitors, Antimalarials, 6827, Tocris Bioscience
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