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Description: Selective TRPA1 activator
Chemical Name: (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
Purity: ≥98% (HPLC)
Biological Activity for ASP 7663
ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.
Technical Data for ASP 7663
| M. Wt | 263.26 |
| Formula | C14H14FNO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1190217-35-6 |
| PubChem ID | 44232532 |
| InChI Key | RCVZUIGCNAAMIC-UXBLZVDNSA-N |
| Smiles | O=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ASP 7663
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.33 | 100 | |
| ethanol | 26.33 | 100 |
Preparing Stock Solutions for ASP 7663
The following data is based on the product molecular weight 263.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.8 mL | 18.99 mL | 37.99 mL |
| 5 mM | 0.76 mL | 3.8 mL | 7.6 mL |
| 10 mM | 0.38 mL | 1.9 mL | 3.8 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets for ASP 7663
References for ASP 7663
References are publications that support the biological activity of the product.
Kojima et al (2014) Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 723 288 PMID: 24291101
If you know of a relevant reference for ASP 7663, please let us know.
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Keywords: ASP 7663, ASP 7663 supplier, ASP7663, transient, receptor, potential, ankyrin, 1, selective, TRPA1, activators, activates, anticonstipation, abdominal, analgesics, 5HT, 5178, Tocris Bioscience
2 Citations for ASP 7663
Citations are publications that use Tocris products. Selected citations for ASP 7663 include:
Ko et al (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep 9 2430 PMID: 30787340
Blaha et al (2019) Bladder Dysfunction in an Obese Zucker Rat: The Role of TRPA1 Channels, Oxidative Stress, and Hydrogen Sulfide. Oxid Med Cell Longev 2019 5641645 PMID: 31531184
Do you know of a great paper that uses ASP 7663 from Tocris? Please let us know.
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