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Submit ReviewAT 1015
Description: Long-acting 5-HT2A antagonist
Chemical Name: N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]ethyl]-1-formyl-4-piperidinecarboxamide hydrochloride
Purity: ≥97% (HPLC)
Biological Activity for AT 1015
AT 1015 is a long-acting 5-HT2A receptor antagonist; inhibits vasoconstriction and blocks platelet aggregation. Prolongs clotting time in a rat model of thrombus formation; ameliorates laurate-induced peripheral vascular lesions in rodents.
Technical Data for AT 1015
| M. Wt | 492.05 |
| Formula | C29H33N3O2.HCl |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 190508-50-0 |
| PubChem ID | 9805663 |
| InChI Key | YZHGXYNLMHGNJZ-UHFFFAOYSA-N |
| Smiles | O=C(C5CCN(C=O)CC5)NCCN(CC3)CC/C3=C1C(C=CC=C4)=C4C=CC2=C\1C=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AT 1015
References for AT 1015
References are publications that support the biological activity of the product.
Rashid et al (2001) Assessment of affinity and dissociation ability of a newly synthesized 5-HT2 antagonist, AT-1015: comparison with other 5-HT2 antagonists. Jpn.J.Pharmacol. 87 189 PMID: 11885967
Kihara et al (2000) AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2A receptors and prevents the laurate-induced peripheral vascular lesions in rats. J.Cardiovasc.Pharmacol. 35 523 PMID: 10774780
Kihara et al (2001) Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time. Eur.J.Pharmacol. 433 157 PMID: 11755147
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Citations for AT 1015
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Currently there are no citations for AT 1015.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.