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Submit ReviewATPγS tetralithium salt
Description: Non-selective P2 agonist; analog of ATP (Cat. No. 3245)
Alternative Names: ATP-γS
Chemical Name: Adenosine-5'-(γ-thio)-triphosphate tetralithium salt
Purity: ≥85% (HPLC)
Biological Activity for ATPγS tetralithium salt
ATPγS tetralithium salt is a P2 purinergic receptor agonist. Nonhydrolyzable analog of ATP (Cat. No. 3245).
Technical Data for ATPγS tetralithium salt
| M. Wt | 546.98 |
| Formula | C10H12Li4N5O12P3S |
| Storage | Store at -20°C |
| Purity | ≥85% (HPLC) |
| CAS Number | 93839-89-5 |
| PubChem ID | 5311341 |
| InChI Key | DWQFDOIBOYDYKH-KWIZKVQNSA-J |
| Smiles | NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])([O-])=S)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ATPγS tetralithium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.35 | 50 |
Preparing Stock Solutions for ATPγS tetralithium salt
The following data is based on the product molecular weight 546.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.66 mL | 18.28 mL | 36.56 mL |
| 2.5 mM | 0.73 mL | 3.66 mL | 7.31 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 25 mM | 0.07 mL | 0.37 mL | 0.73 mL |
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Product Datasheets for ATPγS tetralithium salt
References for ATPγS tetralithium salt
References are publications that support the biological activity of the product.
Evans et al (1995) Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2X purinoceptors). Mol.Pharmacol. 48 178 PMID: 7544432
Peck and Herschlag (2003) Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9 1180 PMID: 13130132
Chrysogelos et al (1983) The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate). J.Biol.Chem. 258 12624 PMID: 6313668
If you know of a relevant reference for ATPγS tetralithium salt, please let us know.
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Keywords: ATPgammaS tetralithium salt, ATPgammaS tetralithium salt supplier, ATPgammaS, ATPγ, ATPgS, ATP, analogs, purinergic, receptors, p2x, p2y, purinoceptors, agonists, ATP-gS, ATP-yS, P2X, Receptors, Purinergic, P2Y, 4080, Tocris Bioscience
7 Citations for ATPγS tetralithium salt
Citations are publications that use Tocris products. Selected citations for ATPγS tetralithium salt include:
Jean-Michel et al (2021) Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner. Elife 10 PMID: 34842136
Timothy S et al (2021) Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol 207 1275-1287 PMID: 34389624
Aho et al (2016) Extracellular ATP protects endothelial cells against DNA damage. Purinergic Signal 12 575 PMID: 27030122
Ke et al (2020) A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome. Cell Chem Biol 27 1073-1083.e12 PMID: 32521230
Handly & Wollman (2017) Wound-induced Ca2+ wave propagates through a simple release and diffusion mechanism. Mol Biol Cell 28 1457 PMID: 28404746
Miguel Cruz & Beall et al (2020) Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance Front Physiol 11 PMID: 33101053
Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767 PMID: 25533845
Do you know of a great paper that uses ATPγS tetralithium salt from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.