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Submit ReviewAUNP 12
Description: Peptide inhibitor of the PD-1 signaling pathway
Purity: ≥95% (HPLC)
Biological Activity for AUNP 12
AUNP 12 is an immune checkpoint modulator targeting the programmed cell death 1 (PD-1) signaling pathway. It inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2. In the mouse splenocyte assay system, AUNP 12 rescues proliferation (EC50 values are 17 and 16 nM for PD-L1 and PD-L2, respectively) and enhances T-cell activity by restoring IFNγ release inhibited by PD-L1 and PD-L2 (EC50 values are 49 nM and 51 nM respectively). In a mouse Renca renal cell carcinoma model, AUNP 12 shows an additive antitumor effect when combined with Cyclophosphamide (Cat. No. 4091).
Technical Data for AUNP 12
| M. Wt | 3261.56 |
| Formula | C142H226N40O48 |
| Sequence |
SNTSESFKFRVTQLAPKAQIKE SNTSESF* (Modifications: Amide bridge= 8-7*, Glu-22 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1353563-85-5 |
| PubChem ID | 154701623 |
| InChI Key | ZBJUUYIGBAQYBN-QKLNNLIKSA-N |
| Smiles | OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@H](CC)C)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)=O)=O)=O)CCCCNC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC(N)=O)NC([C@H](CO)N)=O)=O)=O)=O)CCC(O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)=O)C(C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)=O)=O)C)=O)CCC(N)=O)=O)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AUNP 12
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for AUNP 12
References for AUNP 12
References are publications that support the biological activity of the product.
Omstead et al (2022) CSF-1R inhibitor, pexidartinib, sensitizes esophageal adenocarcinoma to PD-1 immune checkpoint blockade in a rat model. Carcinogenesis 43 842 PMID: 35552655
Sasikumar et al (2019) A rationally designed peptide antagonist of the PD-1 signaling pathway as an immunomodulatory agent for cancer therapy. Mol.Cancer Ther. 18 1081 PMID: 31015307
Zhan et al (2016) From monoclonal antibodies to small molecules: the development of inhibitors targeting the PD-1/PD-L1 pathway. Drug Discov.Today 21 1027 PMID: 27094104
If you know of a relevant reference for AUNP 12, please let us know.
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Keywords: AUNP 12, AUNP 12 supplier, AUNP12, immune, checkpoint, programmed, cell, death, 1, PD-1, PD-L1, PD-L2, IFN, gamma, Interferon, Other, Apoptosis, Immune, Checkpoints, 7831, Tocris Bioscience
Citations for AUNP 12
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