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Submit ReviewAZ 12080282 dihydrochloride
Description: Inhibitor of Hedgehog (Hh) signaling
Chemical Name: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for AZ 12080282 dihydrochloride
AZ 12080282 dihydrochloride is an inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for AZ 12080282 dihydrochloride
| M. Wt | 457.35 |
| Formula | C23H20N4O2.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 78243727 |
| InChI Key | CPORFOBFIDPDLZ-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C2=NC=CN2)C=C1NC(C3=CC=C(OCC4=CC=CC=N4)C=C3)=O.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AZ 12080282 dihydrochloride
References for AZ 12080282 dihydrochloride
References are publications that support the biological activity of the product.
Yang et al (2012) Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg.Med.Chem.Lett. 22 4907 PMID: 22704236
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