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Submit ReviewAZ 12216052
Discontinued Product
4832 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Positive allosteric modulator of mGlu8 receptors
Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide
Purity: ≥97% (HPLC)
Biological Activity for AZ 12216052
AZ 12216052 is a positive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.
Technical Data for AZ 12216052
| M. Wt | 392.35 |
| Formula | C19H22BrNOS |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1290628-31-7 |
| PubChem ID | 73755190 |
| InChI Key | QKUYZJOTWYRWNF-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(CSCC(NC2=CC=C(C(C)CC)C=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AZ 12216052
References for AZ 12216052
References are publications that support the biological activity of the product.
Chruscicka et al (2013) Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep. 65 38
Duvoisin et al (2011) Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 221 50 PMID: 21382421
Duvoisin et al (2010) Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 212 168 PMID: 20385173
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Keywords: AZ 12216052, AZ 12216052 supplier, AZ12216052, anxiolytics, mGluR8, positive, allosteric, modulators, PAMs, Glutamate, (Metabotropic), Group, III, Receptors, 4832, Tocris Bioscience
Citations for AZ 12216052
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Currently there are no citations for AZ 12216052.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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