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Description: mGlu5 antagonist; orally bioavailable and brain penetrant
Chemical Name: 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine
Purity: ≥98% (HPLC)
Biological Activity for AZD 2066
AZD 2066 is an mGlu5 antagonist. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.
Compound Libraries for AZD 2066
AZD 2066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AZD 2066
| M. Wt | 381.82 |
| Formula | C19H16ClN5O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 934282-55-0 |
| PubChem ID | 16041426 |
| InChI Key | SXWHYTICXCLKDG-GFCCVEGCSA-N |
| Smiles | CN1C(C2=CC=NC=C2)=NN=C1O[C@H](C)C3=NOC(C4=CC=CC(Cl)=C4)=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AZD 2066
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.18 | 100 | |
| ethanol | 38.18 | 100 |
Preparing Stock Solutions for AZD 2066
The following data is based on the product molecular weight 381.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.1 mL | 26.19 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for AZD 2066
References for AZD 2066
References are publications that support the biological activity of the product.
Swedberg et al (2014) AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 350 212 PMID: 24876235
If you know of a relevant reference for AZD 2066, please let us know.
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Keywords: AZD 2066, AZD 2066 supplier, AZD2066, mGlu5, antagonists, metabotropic, glutamate, receptors, orally, bioavailable, brain, penetrant, Glutamate, (Metabotropic), Group, I, Receptors, 5614, Tocris Bioscience
Citations for AZD 2066
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Currently there are no citations for AZD 2066. Do you know of a great paper that uses AZD 2066 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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