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B I09

Cat. No. 6009 1 Citation Submit a Review Datasheet / COA / SDS
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Description: IRE1 endonuclease inhibitor; cell permeable
Chemical Name: 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for B I09

B I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

Compound Libraries for B I09

B I09 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for B I09

M. Wt 303.31
Formula C16H17NO5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1607803-67-7
PubChem ID 86290458
InChI Key UYYMWNUDIOPESF-UHFFFAOYSA-N
Smiles OC1=CC=C2C3=C(C(OC2=C1C4OCCCO4)=O)CNCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for B I09

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.17 50

Preparing Stock Solutions for B I09

The following data is based on the product molecular weight 303.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.59 mL 32.97 mL 65.94 mL
2.5 mM 1.32 mL 6.59 mL 13.19 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for B I09

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for B I09

References are publications that support the biological activity of the product.

Tang et al (2014) Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest. 124 2585 PMID: 24812669

If you know of a relevant reference for B I09, please let us know.

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Keywords: B I09, B I09 supplier, BI09, IRE, inhibitors, inhibits, cell, permeable, in, vivo, active, RNAse, endonuclease, IRE1, 6009, Tocris Bioscience

1 Citation for B I09

Citations are publications that use Tocris products. Selected citations for B I09 include:

Andrew V et al (2021) Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers. Cancer Res 81 5325-5335 PMID: 34548333

Do you know of a great paper that uses B I09 from Tocris? Please let us know.

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Literature in this Area

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

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