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Description: 5- and 12-Lipoxygenase inhibitor
Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Biological Activity for Baicalein
Baicalein is an inhibitor of 5- and platelet 12-lipoxygenases (IC50 values are 9.5 and 0.12 μM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF-κB activation. Also inhibits erastin-induced ferroptosis.
Technical Data for Baicalein
| M. Wt | 270.24 |
| Formula | C15H10O5 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 491-67-8 |
| PubChem ID | 5281605 |
| InChI Key | FXNFHKRTJBSTCS-UHFFFAOYSA-N |
| Smiles | OC1=C(O)C(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Baicalein
References for Baicalein
References are publications that support the biological activity of the product.
Hsu et al (2001) Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules. Eur.J.Pharmacol. 425 165 PMID: 11513834
Nakahata et al (2003) Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Eur.J.Pharmacol. 461 1 PMID: 12568909
Sekiya and Okuda (1982) Selective inhibition of platelet lipoxygenase by baicalein. Biochem.Biophys.Res.Commun. 105 1090 PMID: 6807310
Hsieh et al (2007) Baicalein inhibits IL-1β- and TNFα-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. Clin.Mol.Allergy 26 5 PMID: 18039391
Xie et al (2016) Identification of Baicalein as a ferroptosis inhibitor by natural product library screening. Biochem.Biophys.Res.Commun. 473 775 PMID: 27037021
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Keywords: Baicalein, Baicalein supplier, Induces, G1, G2, cell, cycle, arrest, lipoxygenase, inhibitors, inhibits, 5-Lipoxygenase, platelet, 12-Lipoxygenase, Cell, Cycle, Lipoxygenase, Oxygenases, Oxidases, 5-LOX, 12-LOX, Inhibitors, Ferroptosis, 1761, Tocris Bioscience
6 Citations for Baicalein
Citations are publications that use Tocris products. Selected citations for Baicalein include:
Oguh-Olayinka et al (2019) The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res PMID: 30941737
Starowicz et al (2013) Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. PLoS One 8 e60040 PMID: 23573230
Mishra et al (2017) Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol 2 17072 PMID: 28504669
Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. PLoS One 8 e73929 PMID: 24069252
Maskrey et al (2014) 12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition. PLoS One 11 33 PMID: 25349537
Gibson et al (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 746 PMID: 18341994
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