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Submit ReviewBAN ORL 24
Description: Potent and selective NOP antagonist
Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide dihydrochloride
Purity: ≥97% (HPLC)
Biological Activity for BAN ORL 24
Potent and selective NOP receptor antagonist (IC50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors respectively). Inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. Brain penetrant.
Technical Data for BAN ORL 24
| M. Wt | 506.51 |
| Formula | C27H35N3O2.2HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1401463-54-4 |
| PubChem ID | 56840444 |
| InChI Key | NEEVITHVDIQNJY-KHZPMNTOSA-N |
| Smiles | O=[C@@]([C@H]2CCCN2CC3=CC=CC=C3)NCCCN1CCC4(OCC5=C4C=CC=C5)CC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BAN ORL 24
References for BAN ORL 24
References are publications that support the biological activity of the product.
Goto et al (2006) Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity. J.Med.Chem. 49 847 PMID: 16451050
Liao et al (2009) 1-Benzyl-N-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices. Eur.J.Pharmacol. 606 84 PMID: 19374842
Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50 PMID: 19445927
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Keywords: BAN ORL 24, BAN ORL 24 supplier, BANORL24, potent, selective, NOP, ORL1, OP4, nociceptin, orphanin, FQ, opioids, receptor-like, 1, receptors, antagonists, Receptors, 3661, Tocris Bioscience
1 Citation for BAN ORL 24
Citations are publications that use Tocris products. Selected citations for BAN ORL 24 include:
Aatsinki et al (2014) MetF. induces PGC-1α expression and selectively affects hepatic PGC-1α functions. Am J Physiol Cell Physiol 171 2351 PMID: 24428821
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.