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Submit ReviewBAY 1797
Description: Selective P2X4 antagonist
Chemical Name: N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
Purity: ≥98% (HPLC)
Biological Activity for BAY 1797
BAY 1797 is a selective purinergic P2X4 receptor antagonist (IC50 values are 108, 112 and 233 nM for the human, mouse and rat P2X4, respectively). It is selective for P2X4 over P2X3, P2X7, and P2X1 receptors (IC50 values are 8.3, 10.6 and >50 μM, respectively, for the human receptors). BAY 1797 dose-dependently reduces prostaglandin E2 levels and exhibits anti-inflammatory and analgesic effects in an in vivo model of inflammatory pain. Orally active.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 1797 probe summary on the SGC website.
Technical Data for BAY 1797
| M. Wt | 416.88 |
| Formula | C20H17ClN2O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2055602-83-8 |
| PubChem ID | 124125214 |
| InChI Key | CSJYMAFXYMYNCK-UHFFFAOYSA-N |
| Smiles | NS(=O)(C1=C(C=CC(NC(CC2=CC=CC=C2)=O)=C1)OC3=CC(Cl)=CC=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAY 1797
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.69 | 100 | |
| ethanol | 41.69 | 100 |
Preparing Stock Solutions for BAY 1797
The following data is based on the product molecular weight 416.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.4 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for BAY 1797
References for BAY 1797
References are publications that support the biological activity of the product.
Werner et al (2019) Discovery and characterization of the potent and selective P2X4 inhibitor N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and structure-guided amelioration of its CYP3A4 induction profile. J.Med.Chem. 62 11194 PMID: 31746599
If you know of a relevant reference for BAY 1797, please let us know.
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Keywords: BAY 1797, BAY 1797 supplier, BAY1797, selective, antagonizes, antagonists, purinergic, P2X4, receptor, antinociceptive, anti-inflammatory, P2X, Receptors, 7573, Tocris Bioscience
Citations for BAY 1797
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.