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Description: Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable
Chemical Name: (1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol
Purity: ≥98% (HPLC)
Biological Activity for BAY 390
BAY 390 is a potent and selective transient receptor potential ankyrin 1 (TRPA1) antagonist (IC50 values are 16, 63 and 82 nM for hTRPA1 FLIPR, rTRPA1 FLIPR and hTRPA1 Ephys, respectively). In vivo, BAY 390 exhibits efficacy in rat models of inflammatory and neuropathic pain. BAY 390 is orally bioavailable and brain penetrant. Suitable to use as an in vitro or in vivo probe to investigate the roles of TRPA1 in models of acute, inflammatory, and neuropathic pain.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 390 probe summary on the SGC website.
Technical Data for BAY 390
| M. Wt | 277.26 |
| Formula | C13H15F4NO |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2741956-55-6 |
| PubChem ID | 155539293 |
| InChI Key | IESAJAZKMLPVIB-VXGBXAGGSA-N |
| Smiles | FC(F)([C@]1(CCCC[C@H]1NC2=CC=C(F)C=C2)O)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAY 390
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.73 | 100 | |
| ethanol | 27.73 | 100 |
Preparing Stock Solutions for BAY 390
The following data is based on the product molecular weight 277.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.61 mL | 18.03 mL | 36.07 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.21 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.61 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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Product Datasheets for BAY 390
References for BAY 390
References are publications that support the biological activity of the product.
Mesch et al (2023) Discovery of BAY-390, a selective CNS penetrant chemical probe as transient receptor potential ankyrin 1 (TRPA1) antagonist. J.Med.Chem. 66 1583 PMID: 36622903
If you know of a relevant reference for BAY 390, please let us know.
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