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BAY 593

Cat. No. 8113 Submit a Review Datasheet / COA / SDS
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Description: Geranylgeranyltransferase-I (GGTase-I) inhibitor
Chemical Name: (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BAY 593

BAY 593 is a geranylgeranyltransferase-I (GGTase-I) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC50 values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use in vivo.

Technical Data for BAY 593

M. Wt 513
Formula C26H31F3N2O3.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2413020-57-0
InChI Key OCVVGTVEVMMMCR-XSHMPXIGSA-N
Smiles COC1=C(C=CC=C1)[C@H]2C3(CCNC2)CCN(CC3)C([C@](OC)(C4=CC=CC=C4)C(F)(F)F)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 593

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.3 100

Preparing Stock Solutions for BAY 593

The following data is based on the product molecular weight 513. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.75 mL 19.49 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for BAY 593

References are publications that support the biological activity of the product.

Graham et al (2024) Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell.Chem.Biol. 31 1247 PMID: 38537632

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Keywords: BAY 593, BAY 593 supplier, BAY593, GGTase, inhibitor, inhibitors, inhibits, Rho-GTPase, GTPase, YAP1, TAZ, Other, Transferases, 8113, Tocris Bioscience

Citations for BAY 593

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