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Submit ReviewBAY-X 1005
Description: Orally active 5-lipoxygenase activating protein (FLAP) inhibitor
Chemical Name: (R)-α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
Purity: ≥98% (HPLC)
Biological Activity for BAY-X 1005
BAY-X 1005 is a 5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B4 and C4 in animal models; inhibits synthesis of leukotriene B4 in A23187-stimulated leukocytes (IC50 values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.
Technical Data for BAY-X 1005
| M. Wt | 361.43 |
| Formula | C23H23NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 128253-31-6 |
| PubChem ID | 123723 |
| InChI Key | ZEYYDOLCHFETHQ-JOCHJYFZSA-N |
| Smiles | O=[C@@]([C@H](C4CCCC4)C(C=C3)=CC=C3OCC2=NC1=CC=CC=C1C=C2)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BAY-X 1005
References for BAY-X 1005
References are publications that support the biological activity of the product.
Muller-Peddinghaus et al (1993) BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 267 51 PMID: 8229782
Hatzelmann et al (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43 64 PMID: 7741044
Fruchtmann et al (1993) In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 38 188 PMID: 8213345
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Keywords: BAY-X 1005, BAY-X 1005 supplier, BAY-X1005, 5-lipoxygenase, activating, protein, FLAP, inhibitors, inhibits, leukotriene, synthesis, signaling, signalling, antiinflammatory, 5-LOX, Lipoxygenase, Leukotriene, and, Related, Receptors, 3541, Tocris Bioscience
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