Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBazedoxifene acetate
Description: Potent and selective estrogen receptor modulator (SERM)
Chemical Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate
Purity: ≥98% (HPLC)
Biological Activity for Bazedoxifene acetate
Bazedoxifene acetate is a potent selective estrogen receptor modulator (SERM) (IC50 values are 26 and 99 nM for ERα and ERβ respectively). Inhibits 17β-estradiol-induced proliferation in MCF-7 cells. Co-treatment with Raloxifene (Cat. No. 2280) completely abolishes raloxifene-induced stimulation of luminal epithelial cells and myometrium.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Bazedoxifene acetate
Bazedoxifene acetate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Bazedoxifene acetate
| M. Wt | 530.65 |
| Formula | C30H34N2O3.C2H4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 198481-33-3 |
| PubChem ID | 154256 |
| InChI Key | OMZAMQFQZMUNTP-UHFFFAOYSA-N |
| Smiles | CC2=C(C3=CC=C(O)C=C3)N(CC4=CC=C(OCCN5CCCCCC5)C=C4)C1=CC=C(O)C=C12.OC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bazedoxifene acetate
References for Bazedoxifene acetate
References are publications that support the biological activity of the product.
Komm et al (2005) Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology 146 3999 PMID: 15961563
View Related Products by Target
View Related Products by Product Action
Keywords: Bazedoxifene acetate, Bazedoxifene acetate supplier, selective, estrogen, receptors, modulator, SERM, for, ERα, Estrogen, and, Related, Receptors, 5263, Tocris Bioscience
Citations for Bazedoxifene acetate
Citations are publications that use Tocris products.
Currently there are no citations for Bazedoxifene acetate.
Reviews for Bazedoxifene acetate
There are currently no reviews for this product. Be the first to review Bazedoxifene acetate and earn rewards!
Have you used Bazedoxifene acetate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Pathways for Bazedoxifene acetate
