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Submit ReviewBetaxolol hydrochloride
Description: Selective β1 antagonist
Chemical Name: 1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Betaxolol hydrochloride
Betaxolol hydrochloride is a selective β1-adrenoceptor antagonist.
Technical Data for Betaxolol hydrochloride
| M. Wt | 343.89 |
| Formula | C18H29NO3.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 63659-19-8 |
| PubChem ID | 107952 |
| InChI Key | CHDPSNLJFOQTRK-UHFFFAOYSA-N |
| Smiles | Cl.CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Betaxolol hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.19 | 50 |
Preparing Stock Solutions for Betaxolol hydrochloride
The following data is based on the product molecular weight 343.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.82 mL | 29.08 mL | 58.16 mL |
| 2.5 mM | 1.16 mL | 5.82 mL | 11.63 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
| 25 mM | 0.12 mL | 0.58 mL | 1.16 mL |
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Product Datasheets for Betaxolol hydrochloride
References for Betaxolol hydrochloride
References are publications that support the biological activity of the product.
Beresford and Heel (1986) Betaxolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in hypertension. Drugs 31 6 PMID: 2866947
Satoh et al (1993) The affinity of betaxolol, a β1-adrenoceptor-selective blocking agent, for β-adrenoceptors in the bovine trachea and heart Br.J.Pharmacol. 108 484 PMID: 8383566
Setoguchi et al (1995) Inhibitory action of betaxolol, a β1-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea pig artery and vein. Br.J.Pharmacol. 115 198 PMID: 7647977
Merck Index 12 1229
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5 Citations for Betaxolol hydrochloride
Citations are publications that use Tocris products. Selected citations for Betaxolol hydrochloride include:
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600
Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci 31 14172 PMID: 21976502
Nobis et al (2011) β-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism. Biol Psychiatry 69 1083 PMID: 21334600
Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Cardiovasc Res 355 183 PMID: 26306764
Nackley et al (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 128 199 PMID: 17084978
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.