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BETP

Cat. No. 4778 Submit a Review Datasheet / COA / SDS
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Description: Positive allosteric modulator of GLP-1 receptors
Chemical Name: 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BETP

BETP is a selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors.

Compound Libraries for BETP

BETP is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BETP

M. Wt 406.42
Formula C20H17F3N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1371569-69-5
PubChem ID 49868481
InChI Key NTDFYGSSDDMNHI-UHFFFAOYSA-N
Smiles CCS(C1=NC(C2=CC=CC(OCC3=CC=CC=C3)=C2)=CC(C(F)(F)F)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BETP

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.64 100
ethanol 20.32 50

Preparing Stock Solutions for BETP

The following data is based on the product molecular weight 406.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Reconstitution Calculator

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References for BETP

References are publications that support the biological activity of the product.

Willard et al (2012) Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the Insotropic effect of oxyntomodulin. Mol.Pharmacol. 82 1066 PMID: 22930710

Sloop et al (2010) Novel small molecule glucagon-like peptide-1 receptor agonist stimulates Ins secretion in rodents and from human islets. Diabetes 59 3099 PMID: 20823098

Cheong et al (2012) Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem.Biophys.Res.Comm. 417 558 PMID: 22177947

If you know of a relevant reference for BETP, please let us know.

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Keywords: BETP, BETP supplier, Allosteric, modulators, GLP-1, GLP1, receptors, glucagon-like, peptide, agonists, PAM, Glucagon-Like, Peptide, 1, Receptors, 4778, Tocris Bioscience

Citations for BETP

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Reviews for BETP

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.