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Submit ReviewBF 2649 hydrochloride
Description: Potent and selective H3 inverse agonist
Chemical Name: 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for BF 2649 hydrochloride
BF 2649 hydrochloride is a potent and selective histamine H3 receptor inverse agonist (EC50 = 1.5 nM, Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant.
Compound Libraries for BF 2649 hydrochloride
BF 2649 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BF 2649 hydrochloride
| M. Wt | 332.31 |
| Formula | C17H26ClNO.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 903576-44-3 |
| PubChem ID | 11551689 |
| InChI Key | XLFKECRRMPOAQS-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BF 2649 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.23 | 100 | |
| DMSO | 33.23 | 100 |
Preparing Stock Solutions for BF 2649 hydrochloride
The following data is based on the product molecular weight 332.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.05 mL | 30.09 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for BF 2649 hydrochloride
References for BF 2649 hydrochloride
References are publications that support the biological activity of the product.
Ligneau et al (2007) Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochem.Pharmacol. 73 1215 PMID: 17343831
Ligneau et al (2007) BF2.649 [1-{3-{3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J.Pharm.Exp.Ther. 320 365 PMID: 17005916
If you know of a relevant reference for BF 2649 hydrochloride, please let us know.
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Keywords: BF 2649 hydrochloride, BF 2649 hydrochloride supplier, BF2649, HCl, histamine, receptor, H3, histaminergic, antagonists, inverse, agonists, nootropic, Histamine, Receptors, 3743, Tocris Bioscience
Citations for BF 2649 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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