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Submit ReviewBiperiden hydrochloride
Description: Muscarinic receptor antagonist; some selectivity for M1
Alternative Names: Akineton
Chemical Name: α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Biperiden hydrochloride
Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.
Technical Data for Biperiden hydrochloride
| M. Wt | 347.92 |
| Formula | C21H29NO.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1235-82-1 |
| PubChem ID | 92151 |
| InChI Key | RDNLAULGBSQZMP-UHFFFAOYSA-N |
| Smiles | OC(CCN3CCCCC3)(C4=CC=CC=C4)C1CC2C=CC1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Biperiden hydrochloride
References for Biperiden hydrochloride
References are publications that support the biological activity of the product.
Bolden et al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576 PMID: 1346637
Sudo et al (1999) Muscarinic receptor occupancy by bipe. in living human brain. Life Sci. 64 PL99 PMID: 10069534
Brocks (1999) Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci. 2 39
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.