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BMS 566419

Cat. No. 5492 Submit a Review Datasheet / COA / SDS
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Description: Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Chemical Name: N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BMS 566419

BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Technical Data for BMS 566419

M. Wt 487.57
Formula C28H30FN5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 566161-24-8
PubChem ID 9913339
InChI Key XEVJUIZOZCFECP-UHFFFAOYSA-N
Smiles O=C2C3=C(C=C(C(NC(C)(C)C4=CC=C(N5CCN(CC)CC5)N=C4)=O)C(F)=C3)NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 566419

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 24.38 50
DMSO 48.76 100

Preparing Stock Solutions for BMS 566419

The following data is based on the product molecular weight 487.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.25 mL 20.51 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
10 mM 0.21 mL 1.03 mL 2.05 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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References for BMS 566419

References are publications that support the biological activity of the product.

Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730 PMID: 17585753

If you know of a relevant reference for BMS 566419, please let us know.

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Citations for BMS 566419

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