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Submit ReviewBMY 14802 hydrochloride
Description: Sigma antagonist. Antipsychotic agent
Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for BMY 14802 hydrochloride
BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.
Licensing Information
Sold with the permission of Bristol-Myers Squibb Company
Technical Data for BMY 14802 hydrochloride
| M. Wt | 384.86 |
| Formula | C18H22F2N4O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 105565-55-7 |
| PubChem ID | 3086514 |
| InChI Key | NIBVEFRJDFVQLM-UHFFFAOYSA-N |
| Smiles | Cl.OC(CCCN1CCN(CC1)C1=NC=C(F)C=N1)C1=CC=C(F)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMY 14802 hydrochloride
References for BMY 14802 hydrochloride
References are publications that support the biological activity of the product.
Taylor et al (1993) A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 133 125 PMID: 8232511
Yevich et al (1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35 4516 PMID: 1361578
Zhang et al (1993) Further characterization of the effects of BMY 14802 on DA neuronal activity. Synapse 15 276 PMID: 7908761
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Keywords: BMY 14802 hydrochloride, BMY 14802 hydrochloride supplier, σ, sigma, antagonists, Antipsychotic, agent, General, Receptors, BMY14802, Sigma-Related, 1440, Tocris Bioscience
2 Citations for BMY 14802 hydrochloride
Citations are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:
Bhide et al (2013) The effects of BMY-14802 against L-DOPA- and DA agonist-induced dyskinesia in the hemiparkinsonian rat. Psychopharmacology (Berl) 227 533 PMID: 23389756
Paquette et al (2008) σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias. Reprod Biol Endocrinol 19 111 PMID: 18281903
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