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Description: Non-competitive GC inhibitor. Also AC inhibitor
Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
Purity: ≥99% (HPLC)
Biological Activity for BPIPP
Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
Technical Data for BPIPP
| M. Wt | 450.28 |
| Formula | C22H16BrN3O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 325746-94-9 |
| PubChem ID | 4410990 |
| InChI Key | QSZKQDDYOLAPII-UHFFFAOYSA-N |
| Smiles | O=C(C5=C4C=CC=C5)C2=C4NC(N1C)=C(C2C3=CC(Br)=CC=C3)C(N(C)C1=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BPIPP
References for BPIPP
References are publications that support the biological activity of the product.
Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440
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Keywords: BPIPP, BPIPP supplier, Non-competitive, GC, inhibitors, inhibits, Guanylyl, Cyclases, Cyclase, Adenylyl, 3635, Tocris Bioscience
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