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BPTES

Cat. No. 5301 3 Citations 1 Review Submit a Review Datasheet / COA / SDS
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Description: Selective allosteric glutaminase (GLS1) inhibitor
Chemical Name: N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Purity: ≥95% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BPTES

BPTES is an allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

Technical Data for BPTES

M. Wt 524.68
Formula C24H24N6O2S3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 314045-39-1
PubChem ID 3372016
InChI Key MDJIPXYRSZHCFS-UHFFFAOYSA-N
Smiles O=C(NC2=NN=C(CCSCCC4=NN=C(S4)NC(CC3=CC=CC=C3)=O)S2)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BPTES

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.49 20

Preparing Stock Solutions for BPTES

The following data is based on the product molecular weight 524.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.53 mL 47.65 mL 95.3 mL
1 mM 1.91 mL 9.53 mL 19.06 mL
2 mM 0.95 mL 4.76 mL 9.53 mL
10 mM 0.19 mL 0.95 mL 1.91 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for BPTES

References are publications that support the biological activity of the product.

Le et al (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell.Metab. 15 110 PMID: 22225880

Shukla et al (2012) Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J.Med.Chem. 55 10551 PMID: 23151085

DeLaBarre et al (2011) Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50 10764 PMID: 22049910

If you know of a relevant reference for BPTES, please let us know.

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Keywords: BPTES, BPTES supplier, allosteric, glutaminases, gls1, inhibitors, inhibits, selective, Glutaminase, 5301, Tocris Bioscience

3 Citations for BPTES

Citations are publications that use Tocris products. Selected citations for BPTES include:

Ryan M et al (2020) Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Rep 30 2889-2899.e6 PMID: 32130894

Ryan M et al (2023) miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation. Front Genet 14 1192799 PMID: 37229187

Santosh et al (2021) The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep 34 108869 PMID: 33730581

Do you know of a great paper that uses BPTES from Tocris? Please let us know.

Reviews for BPTES

Average Rating: 4 (Based on 1 Review.)

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GLS inhibition.
By Anonymous on 09/20/2018
Species: Human

incubation, slight effect

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