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Submit ReviewBRD 4354
Description: HDAC5 and HDAC9 inhibitor
Chemical Name: 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol
Purity: ≥98% (HPLC)
Biological Activity for BRD 4354
BRD 4354 is a HDAC5 and HDAC9 inhibitor (IC50 values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.
Technical Data for BRD 4354
| M. Wt | 382.89 |
| Formula | C21H23ClN4O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 315698-07-8 |
| PubChem ID | 3516032 |
| InChI Key | XAFSFXYJOJWLJD-UHFFFAOYSA-N |
| Smiles | CCN1CCN(C(C2=C(C3=C(C(Cl)=C2)C=CC=N3)O)C4=CN=CC=C4)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BRD 4354
References for BRD 4354
References are publications that support the biological activity of the product.
Boskovic et al (2016) Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. ACS Chem.Biol. 11 1844 PMID: 27064299
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Keywords: BRD 4354, BRD 4354 supplier, BRD4354, HDAC5, HDAC9, selective, histone, deacetylases, inhibitors, inhibits, Class, II, HDACs, 6010, Tocris Bioscience
Citations for BRD 4354
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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