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Submit ReviewBRD 7116
Description: Inhibitor of leukemia stem cell activity
Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethylcyclopropanecarboxamide]
Purity: ≥98% (HPLC)
Biological Activity for BRD 7116
Inhibitor of leukemia stem cell (LSC) activity (EC50 = 200 nM). Exhibits >100-fold selectivity for LSCs over normal hematopoietic stem cells.
Technical Data for BRD 7116
| M. Wt | 496.66 |
| Formula | C28H36N2O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 329059-55-4 |
| PubChem ID | 981129 |
| InChI Key | UHXFWAHRAMUDLJ-UHFFFAOYSA-N |
| Smiles | O=C(C1C(C)(C)C1(C)C)NC(C=C2)=CC=C2S(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BRD 7116
References for BRD 7116
References are publications that support the biological activity of the product.
Hartwell et al (2013) Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat.Chem.Biol. 9 840 PMID: 24161946
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Keywords: BRD 7116, BRD 7116 supplier, BRD7116, leukemia, stem, cells, inhibitors, inhibits, LSCs, Cancer, Stem, Cells, 5336, Tocris Bioscience
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