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Submit ReviewBRD 73954
Description: Dual histone deacetylase (HDAC) 6/8 inhibitor
Chemical Name: N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
Purity: ≥98% (HPLC)
Biological Activity for BRD 73954
BRD 73954 is a dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively.
Compound Libraries for BRD 73954
BRD 73954 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BRD 73954
| M. Wt | 284.31 |
| Formula | C16H16N2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1440209-96-0 |
| PubChem ID | 71680913 |
| InChI Key | FIHKWEQJEDRIFS-UHFFFAOYSA-N |
| Smiles | ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BRD 73954
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.43 | 100 | |
| ethanol | 5.69 | 20 with gentle warming |
Preparing Stock Solutions for BRD 73954
The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.03 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets for BRD 73954
References for BRD 73954
References are publications that support the biological activity of the product.
Olson et al (2013) Discovery of the first histone deacetylase 6/8 dual inhibitors. J.Med.Chem. 56 4816 PMID: 23672185
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Keywords: BRD 73954, BRD 73954 supplier, BRD73954, Histone, deacetylase, inhibitors, inhibits, HDAC6, HDAC8, HDAC, Class, I, HDACs, II, 6284, Tocris Bioscience
Citations for BRD 73954
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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