Home / Product Type / PROTAC® Degraders & Targeted Protein Degradation / Protein Degraders / Bromodomain (BRD) Degraders / BRD PHOTAC-I-3

BRD PHOTAC-I-3

Cat. No. 7319 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Photoswitchable BET bromodomain Degrader (PHOTAC)
Chemical Name: 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]-[1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(4-((E)-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)diazenyl)-2,6-dimethoxyphenoxy)acetamido)butyl)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BRD PHOTAC-I-3

BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera). BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+)-JQ1 (Cat. No. 4499). Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark. BRD2 antibodies validated for Western Blot also available: Catalog # NBP1-30475 and NBP2-75422.

Licensing Information

Sold under license from New York University

Technical Data for BRD PHOTAC-I-3

M. Wt 935.45
Formula C46H47ClN10O8S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2370997-94-5
PubChem ID 154722038
InChI Key SGZZPSOQAWRZGE-RCBZUBGNSA-N
Smiles COC1=CC(/N=N/C2=C3CN(C(C3=CC=C2)=O)C4CCC(NC4=O)=O)=CC(OC)=C1OCC(NCCCCNC(C[C@@H]5N=C(C6=CC=C(C=C6)Cl)C7=C(N8C(C)=NN=C58)SC(C)=C7C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRD PHOTAC-I-3

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.77 50

Preparing Stock Solutions for BRD PHOTAC-I-3

The following data is based on the product molecular weight 935.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.14 mL 10.69 mL 21.38 mL
2.5 mM 0.43 mL 2.14 mL 4.28 mL
5 mM 0.21 mL 1.07 mL 2.14 mL
25 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for BRD PHOTAC-I-3

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for BRD PHOTAC-I-3

References are publications that support the biological activity of the product.

Reynders et al (2020) PHOTACs enable optical control of protein degradation. Sci.Adv. 6 eaay5064 PMID: 32128406

If you know of a relevant reference for BRD PHOTAC-I-3, please let us know.

View Related Products by Target

Keywords: BRD PHOTAC-I-3, BRD PHOTAC-I-3 supplier, PHOTAC, PHOtochemically, TArgeting, Chimeras, chimaeras, photoswitch, photoswitchable, light, activated, BET, bromodomains, BRD2, BRD3, BRD4, Degraders, degrades, targeted, protein, degradation, Bromodomains, Bromodomain, (BRD), 7319, Tocris Bioscience

Citations for BRD PHOTAC-I-3

Citations are publications that use Tocris products.

Currently there are no citations for BRD PHOTAC-I-3. Do you know of a great paper that uses BRD PHOTAC-I-3 from Tocris? Please let us know.

Reviews for BRD PHOTAC-I-3

There are currently no reviews for this product. Be the first to review BRD PHOTAC-I-3 and earn rewards!

Have you used BRD PHOTAC-I-3?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia