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BSJ-03-204

Cat. No. 6938 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective Cdk4/6 Degrader (PROTAC®
Chemical Name: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BSJ-03-204

BSJ-03-204 is a selective Cdk4/6 Degrader (PROTAC®). Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.

CDK4 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF5254 and NBP1-31308.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for BSJ-03-204

M. Wt 832.92
Formula C43H48N10O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2349356-09-6
Smiles CC1=C(C(N(C2=C1C=NC(NC3=CC=C(C=N3)N4CCN(CC4)CCCCNC(COC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)=O)=N2)C8CCCC8)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BSJ-03-204

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.66 20

Preparing Stock Solutions for BSJ-03-204

The following data is based on the product molecular weight 832.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6 mL 30.01 mL 60.03 mL
1 mM 1.2 mL 6 mL 12.01 mL
2 mM 0.6 mL 3 mL 6 mL
10 mM 0.12 mL 0.6 mL 1.2 mL

Molarity Calculator

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References for BSJ-03-204

References are publications that support the biological activity of the product.

Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347

If you know of a relevant reference for BSJ-03-204, please let us know.

View Related Products by Target

Keywords: BSJ-03-204, BSJ-03-204 supplier, protacs, active, degraders, selective, cdk4, cdk6, cyclin, dependent, kinase, degrades, proteolysis, targeting, chimera, PROTAC, CDK4, Subfamily, Cyclin, Dependent, Kinase, (CDK), Degraders, 6938, Tocris Bioscience

1 Citation for BSJ-03-204

Citations are publications that use Tocris products. Selected citations for BSJ-03-204 include:

Daniele et al (2021) A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts. SLAS Discov 26 534-546 PMID: 33445986

Do you know of a great paper that uses BSJ-03-204 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia