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BSJ-4-116-NC

Cat. No. 7529 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Negative control for BSJ-4-116 (Cat. No. 7528)
Chemical Name: N-[7-[(3R)-3-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BSJ-4-116-NC

Negative control for BSJ-4-116 (Cat. No. 7528).

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for BSJ-4-116-NC

M. Wt 851.42
Formula C41H51ClN8O8S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2758598-48-8
PubChem ID 155388076
InChI Key KJALCZZDMXPTHY-RCEYKGAOSA-N
Smiles CC(S(=O)(C1=C(C=CC=C1)NC2=NC(N[C@@H]3CCCN(C3)CCCCCCCNC(COC4=C5C(N(C(C5=CC=C4)=O)C6CCC(N(C)C6=O)=O)=O)=O)=NC=C2Cl)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BSJ-4-116-NC

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 85.14 100

Preparing Stock Solutions for BSJ-4-116-NC

The following data is based on the product molecular weight 851.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.17 mL 5.87 mL 11.75 mL
5 mM 0.23 mL 1.17 mL 2.35 mL
10 mM 0.12 mL 0.59 mL 1.17 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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References for BSJ-4-116-NC

References are publications that support the biological activity of the product.

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View Related Products by Target

Keywords: BSJ-4-116-NC, BSJ-4-116-NC supplier, BSJ4116NC, negative, control, degraders, targeted, protein, degradation, E3, PROTAC, cdk12, kinases, TPD, Negative, Controls, 7529, Tocris Bioscience

Citations for BSJ-4-116-NC

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia