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Submit ReviewBTS 54-505 hydrochloride
Description: Potent 5-HT and NA reuptake inhibitor (SNRI); active metabolite of sibutramine (Cat. No. 2290)
Chemical Name: 1-(4-Chlorophenyl)-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for BTS 54-505 hydrochloride
BTS 54-505 hydrochloride is a potently active primary amine metabolite of sibutramine (Cat. No. 2290), exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro. Reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis in vivo.
Technical Data for BTS 54-505 hydrochloride
| M. Wt | 288.26 |
| Formula | C15H22NCl.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 84484-78-6 |
| PubChem ID | 134771 |
| InChI Key | KHRVYINTXCWNRF-UHFFFAOYSA-N |
| Smiles | Cl.CC(C)CC(N)C1(CCC1)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BTS 54-505 hydrochloride
References for BTS 54-505 hydrochloride
References are publications that support the biological activity of the product.
Luscombe et al (1989) The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutr. hydrochloride. Neuropharmacology 28 129 PMID: 2541365
Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutr. is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373
Liu et al (2002) Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutr. Int.J.Obes.Relat.Metab.Disord. 26 1245 PMID: 12187403
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Citations for BTS 54-505 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.