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Submit ReviewBU 226 hydrochloride
Description: Potent, highly selective I2 ligand
Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)isoquinoline hydrochloride
Biological Activity for BU 226 hydrochloride
BU 226 hydrochloride is a high affinity ligand for I2 imidazoline sites (Ki = 2.7 nM) with very high selectivity (> 2000-fold) over α2-adrenoceptors (Ki = 6700 nM).
Technical Data for BU 226 hydrochloride
| M. Wt | 233.7 |
| Formula | C12H11N3.HCl |
| Storage | Store at RT |
| CAS Number | 1186195-56-1 |
| PubChem ID | 56972194 |
| InChI Key | NIGHNKWLMSRCOZ-UHFFFAOYSA-N |
| Smiles | Cl.C1CN=C(N1)C1=CC2=CC=CC=C2C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BU 226 hydrochloride
References for BU 226 hydrochloride
References are publications that support the biological activity of the product.
Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900
Lione et al (1997) BU226: A selective ligand for rat brain imidazoline I2 sites. Soc.Neurosci.Abstr. 23 695.28
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Keywords: BU 226 hydrochloride, BU 226 hydrochloride supplier, Potent, selective, I2, ligands, Imidazoline, Receptors, BU226, hydrochloride, 1091, Tocris Bioscience
1 Citation for BU 226 hydrochloride
Citations are publications that use Tocris products. Selected citations for BU 226 hydrochloride include:
Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423
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