Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBucindolol
Discontinued Product
2658 has been discontinued.
View all Non-selective Adrenergic β Receptors products.
Description: β1 and β2 antagonist
Alternative Names: MJ 13105
Chemical Name: 2-[2-Hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile
Purity: ≥99% (HPLC)
Biological Activity for Bucindolol
Non-selective β-adrenoceptor antagonist with additional α1-adrenoceptor blocking activity. Ki values are 1.61, 1.20 and 68.9 nM for β1-, β2- and α1-adrenoceptors respectively. Also acts as a weak 5-HT2A/2B antagonist. Displays vasodilatory and antihypertensive actions.
Technical Data for Bucindolol
| M. Wt | 363.45 |
| Formula | C22H25N3O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 71119-11-4 |
| Smiles | CC(NCC(O)COC3=C(C#N)C=CC=C3)(C)CC1=CNC2=C1C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Bucindolol
References for Bucindolol
References are publications that support the biological activity of the product.
Watts et al (2000) Interaction of the [beta] adrenergic receptor antagonist bucindolol with serotonergic receptors. J.Cardiovasc.Pharmacol. 35 29 PMID: 10630730
Ponicke et al (2002) Differential effects of bucindolol and carve. on noradrenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 301 71 PMID: 11907159
Marwood and Stokes (1985) Bucindolol has serotonin and alpha-adrenoceptor blocking properties. J.Cardiovasc.Pharmacol. 7 S67
View Related Products by Target
View Related Products by Product Action
Keywords: Bucindolol, Bucindolol supplier, α1-adrenoceptor, beta1-adrenoceptor, b1-adrenoceptor, b1-adrenergic, β1-Adrenergic, beta1-Adrenergic, α2-adrenoceptor, beta2-adrenoceptor, β2-adrenergic, α2-adrenergic, beta2-adrenergic, b2-adrenoceptor, antagonists, Receptors, Non-Selective, MJ, 13105, Non-selective, Adrenergic, Beta, 2658, Tocris Bioscience
Citations for Bucindolol
Citations are publications that use Tocris products.
Currently there are no citations for Bucindolol.
Reviews for Bucindolol
There are currently no reviews for this product. Be the first to review Bucindolol and earn rewards!
Have you used Bucindolol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.