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Submit ReviewBW 373U86
Discontinued Product
1663 has been discontinued.
Description: Potent, selective non-peptide δ agonist
Chemical Name: 4-[(αR*)-α-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide
Purity: ≥99% (HPLC)
Biological Activity for BW 373U86
BW 373U86 is a potent, selective non-peptide δ-opioid receptor agonist. Ki values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally active following systemic administration in vivo.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for BW 373U86
| M. Wt | 435.61 |
| Formula | C27H37N3O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 155836-50-3 |
| PubChem ID | 119029 |
| InChI Key | LBLDMHBSVIVJPM-YZIHRLCOSA-N |
| Smiles | O=C(N(CC)CC)C1=CC=C([C@@]([H])(N3C[C@@H](C)N(CC=C)C[C@@H]3C)C2=CC(O)=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BW 373U86
References for BW 373U86
References are publications that support the biological activity of the product.
Broom et al (2002) Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice. J.Pharmacol.Exp.Ther. 303 723 PMID: 12388657
Chang et al (1993) A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86. J.Pharmacol.Exp.Ther. 267 852 PMID: 8246159
Dykstra et al (1993) A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration. J.Pharmacol.Exp.Ther. 267 875 PMID: 8246162
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Keywords: BW 373U86, BW 373U86 supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, BW373U86, GlaxoSmithKline, GSK, Delta, Opioid, 1663, Tocris Bioscience
1 Citation for BW 373U86
Citations are publications that use Tocris products. Selected citations for BW 373U86 include:
Donner et al (2013) Obesity improves myocardial ischaemic tolerance and RISK signalling in Ins-insensitive rats. J Allergy Clin Immunol 6 457 PMID: 23161371
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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