Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBYK 191023 dihydrochloride
Description: Potent and selective inhibitor of iNOS
Chemical Name: 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for BYK 191023 dihydrochloride
BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.
Licensing Information
Sold with the permission of Nycomed
Technical Data for BYK 191023 dihydrochloride
| M. Wt | 327.21 |
| Formula | C14H14N4O.2HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1216722-25-6 |
| PubChem ID | 56972216 |
| InChI Key | ZVNITETZYOKESF-UHFFFAOYSA-N |
| Smiles | COC1=CC(CCC2=NC(N=CC=C3)=C3N2)=NC=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BYK 191023 dihydrochloride
References for BYK 191023 dihydrochloride
References are publications that support the biological activity of the product.
Lehner et al (2006) In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase. J.Pharmacol.Exp.Ther. 317 181 PMID: 16368897
Strub et al (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol.Pharmacol. 68 328
Tiso et al (2008) BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol.Pharmacol. 72 1244
View Related Products by Target
View Related Products by Product Action
Keywords: BYK 191023 dihydrochloride, BYK 191023 dihydrochloride supplier, Potent, selective, inhibitors, inhibits, iNOS, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, BYK191023, dihydrochloride, 2866, Tocris Bioscience
Citations for BYK 191023 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for BYK 191023 dihydrochloride.
Reviews for BYK 191023 dihydrochloride
There are currently no reviews for this product. Be the first to review BYK 191023 dihydrochloride and earn rewards!
Have you used BYK 191023 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image