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Submit Reviewc-Di-GMP sodium salt
Description: Endogenous STING and DDX41 agonist; activates STING-dependent signaling
Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt
Purity: ≥98% (HPLC)
Biological Activity for c-Di-GMP sodium salt
c-Di-GMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.
This product is sold in units of 730μg, equivalent to 1μmol.
Technical Data for c-Di-GMP sodium salt
| M. Wt | 734.37 |
| Formula | C20H22N10Na2O14P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2222132-40-1 |
| PubChem ID | 101199074 |
| InChI Key | SVIXOIGPVFFABR-XDODWTFASA-L |
| Smiles | O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for c-Di-GMP sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.69 | 20 |
Preparing Stock Solutions for c-Di-GMP sodium salt
The following data is based on the product molecular weight 734.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 6.81 mL | 34.04 mL | 68.09 mL |
| 1 mM | 1.36 mL | 6.81 mL | 13.62 mL |
| 2 mM | 0.68 mL | 3.4 mL | 6.81 mL |
| 10 mM | 0.14 mL | 0.68 mL | 1.36 mL |
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Product Datasheets for c-Di-GMP sodium salt
References for c-Di-GMP sodium salt
References are publications that support the biological activity of the product.
Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID: 23142775
Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515 PMID: 21947006
Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149 PMID: 26282097
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Keywords: c-Di-GMP sodium salt, c-Di-GMP sodium salt supplier, STING, DDX41, ligands, activates, activators, cancer, immunotherapy, 61093-23-0, STING-Dependent, Signaling, 5900, Tocris Bioscience
Citations for c-Di-GMP sodium salt
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