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Submit ReviewCarbazeran citrate
Description: Aldehyde oxidase substrate; PDE inhibitor
Chemical Name: Ethyl 1-(6,7-dimethoxy-1-phthalazinyl)-4-piperidinyl carbamate citrate
Purity: ≥98% (HPLC)
Biological Activity for Carbazeran citrate
Carbazeran citrate is an aldehyde oxidase (AO) substrate. Exhibits activities as a phosphodiesterase inhibitor; produces concentration-dependent positive inotropic responses in isolated right atria.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Carbazeran citrate
| M. Wt | 552.53 |
| Formula | C18H24N4O4.C6H8O7 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 153473-94-0 |
| PubChem ID | 90488940 |
| InChI Key | QKMRPDVEKBYWPF-UHFFFAOYSA-N |
| Smiles | O=C(NCC)OC(CC3)CCN3C2=NN=CC1=CC(OC)=C(OC)C=C12.OC(CC(C(O)=O)(O)CC(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Carbazeran citrate
References for Carbazeran citrate
References are publications that support the biological activity of the product.
Hutzler et al (2011) Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab.Dispos. 40 267 PMID: 22031625
Shahid and Rodger et al (1989) Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition. Br.J.Pharmacol. 98 291 PMID: 2478244
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Keywords: Carbazeran citrate, Carbazeran citrate supplier, Aldehyde, oxidases, AO, substrates, phosphodiesterase, inhibitors, inhibits, PDE, inotropic, Other, Oxygenases/Oxidases, Phosphodiesterases, 4420, Tocris Bioscience
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