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Carbenoxolone disodium

Cat. No. 3096 5 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase
Chemical Name: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Carbenoxolone disodium

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

Technical Data for Carbenoxolone disodium

M. Wt 614.72
Formula C34H48Na2O7
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 7421-40-1
PubChem ID 636402
InChI Key BQENDLAVTKRQMS-SBBGFIFASA-L
Smiles [Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C(C)(C)[C@]3([H])CC[C@@]12C)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Carbenoxolone disodium

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 61.47 100

Preparing Stock Solutions for Carbenoxolone disodium

The following data is based on the product molecular weight 614.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.13 mL 16.27 mL
5 mM 0.33 mL 1.63 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets for Carbenoxolone disodium

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Carbenoxolone disodium

References are publications that support the biological activity of the product.

Jellinck et al (1993) Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 46 209 PMID: 8664169

Sagar and Larson (2006) Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 98 1543 PMID: 16552723

If you know of a relevant reference for Carbenoxolone disodium, please let us know.

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Keywords: Carbenoxolone disodium, Carbenoxolone disodium supplier, Gap, junction, blockers, inhibitors, inhibits, 11, β-hydroxysteroid, beta-hydroxysteroid, dehydrogenase, gap, Connexins, Channels, Dehydrogenases, 11b-Hydroxysteroid, Dehydrogenase, 3096, Tocris Bioscience

5 Citations for Carbenoxolone disodium

Citations are publications that use Tocris products. Selected citations for Carbenoxolone disodium include:

Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653

Shuhaibar et al (2015) Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A 112 5527 PMID: 25775542

Craig and Martin (2012) Dominance of flow-mediated constriction over flow-mediated dilatation in the rat carotid artery. Br J Pharmacol 167 527 PMID: 22537086

Bhaskaracharya et al (2014) Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. PLoS One 9 e93058 PMID: 24671093

Do you know of a great paper that uses Carbenoxolone disodium from Tocris? Please let us know.

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