Carboxy-PTIO, potassium salt

Discontinued Product

0772 has been discontinued.

View all Other Nitric Oxide products.
Description: Stable, water-soluble deactivator of NO
Chemical Name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt
Datasheet
Citations (11)
Reviews

Biological Activity for Carboxy-PTIO, potassium salt

A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.

Technical Data for Carboxy-PTIO, potassium salt

M. Wt 315.38
Formula C14H16KN2O4
Storage Desiccate at -20°C
CAS Number 148819-94-7
PubChem ID 2733502
InChI Key VYEUQMVIGXFZQU-UHFFFAOYSA-M
Smiles [K+].CC1(C)N([O])C(C2=CC=C(C=C2)C([O-])=O)=[N+]([O-])C1(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Carboxy-PTIO, potassium salt

Certificate of Analysis / Product Datasheet
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References for Carboxy-PTIO, potassium salt

References are publications that support the biological activity of the product.

Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827 PMID: 8422387

Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906 PMID: 8528578

Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55 PMID: 7813579

View Related Products by Target

Keywords: Carboxy-PTIO, potassium salt, Carboxy-PTIO, potassium salt supplier, Stable, water-soluble, deactivators, NO, Nitric, Oxide, Signaling, Signalling, free, radical, Other, 0772, Tocris Bioscience

11 Citations for Carboxy-PTIO, potassium salt

Citations are publications that use Tocris products. Selected citations for Carboxy-PTIO, potassium salt include:

Ormerod et al (2011) The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Br J Pharmacol 89 560 PMID: 20889759

Chan et al (2007) Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia. Mol Pharmacol 71 1129 PMID: 17227955

Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol 97 3386 PMID: 17376843

Quock et al (2011) The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res 1368 102 PMID: 20977894


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