Carboxy-PTIO, potassium salt

Discontinued Product

0772 has been discontinued.

View all Other Nitric Oxide products.
Description: Stable, water-soluble deactivator of NO
Chemical Name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt
Datasheet
Citations (11)
Reviews

Biological Activity for Carboxy-PTIO, potassium salt

A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.

Technical Data for Carboxy-PTIO, potassium salt

M. Wt 315.38
Formula C14H16KN2O4
Storage Desiccate at -20°C
CAS Number 148819-94-7
PubChem ID 2733502
InChI Key VYEUQMVIGXFZQU-UHFFFAOYSA-M
Smiles [K+].CC1(C)N([O])C(C2=CC=C(C=C2)C([O-])=O)=[N+]([O-])C1(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Carboxy-PTIO, potassium salt

Certificate of Analysis / Product Datasheet
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References for Carboxy-PTIO, potassium salt

References are publications that support the biological activity of the product.

Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827 PMID: 8422387

Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906 PMID: 8528578

Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55 PMID: 7813579

View Related Products by Target

Keywords: Carboxy-PTIO, potassium salt, Carboxy-PTIO, potassium salt supplier, Stable, water-soluble, deactivators, NO, Nitric, Oxide, Signaling, Signalling, free, radical, Other, 0772, Tocris Bioscience

11 Citations for Carboxy-PTIO, potassium salt

Citations are publications that use Tocris products. Selected citations for Carboxy-PTIO, potassium salt include:

Carlile et al (2012) An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test. Life Sci 90 267 PMID: 22154905

Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Cardiovasc Res 35 4552 PMID: 25788673

Jin et al (2012) Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol 16 211 PMID: 22802704

Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem 17 221 PMID: 20351057


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