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Submit ReviewCarmoxirole hydrochloride
Description: Selective, peripherally acting D2-like agonist
Alternative Names: EMD 45609
Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indole-5-carboxylic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Carmoxirole hydrochloride
Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Technical Data for Carmoxirole hydrochloride
| M. Wt | 410.94 |
| Formula | C24H26N2O2.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 115092-85-8 |
| PubChem ID | 9822866 |
| InChI Key | LRJUHOBITQUXIO-UHFFFAOYSA-N |
| Smiles | Cl.OC(=O)C1=CC=C2NC=C(CCCCN3CCC(=CC3)C3=CC=CC=C3)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Carmoxirole hydrochloride
References for Carmoxirole hydrochloride
References are publications that support the biological activity of the product.
Haeusler et al (1992) Pharmacological basis for antihypertensive therapy with a novel DA agonist Eur.Heart J. 13 129 PMID: 1356783
Rump et al (1993) DA receptor modulation of noradrenaline release by carmoxirole in human cortical kidney slices. Eur.J.Clin.Pharmacol. 44 S47 PMID: 8097997
Hasse et al (1991) Neurochemical profile of EMD 45609 (carmoxirole), a DA DA2-receptor agonist. Naunyn-Schmied.Arch.Pharmacol. 343 588
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Keywords: Carmoxirole hydrochloride, Carmoxirole hydrochloride supplier, Selective, peripherally, peripheral, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, EMD45609, EMD, 45609, Non-selective, 2193, Tocris Bioscience
2 Citations for Carmoxirole hydrochloride
Citations are publications that use Tocris products. Selected citations for Carmoxirole hydrochloride include:
Schlenker and Schultz (2012) Hypothyroidism stimulates D2 receptor-mediated breathing in response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain. Respir Physiol Neurobiol 180 69 PMID: 22051191
Schlenker et al (2014) Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression. Respir Physiol Neurobiol 193 29 PMID: 24434437
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.